TB-500 (10mg)
Original price was: $98.00.$88.00Current price is: $88.00.
Contents: Lyophilized Powder in 3ml vial
Requires reconstitution with bacteriostatic water
Rigorous Third-Party Testing
Every batch of our research chemicals and peptides undergoes third-party testing.
- Description
- 3rd Party Lab Testing
Description
TB 500
TB 500 (Thymosin Beta 4) is a 43 amino acid synthetic peptide modeled after the naturally occurring Thymosin Beta 4 protein, one of the most extensively studied actin regulating peptides in the published literature. BioEdge Research Labs supplies TB 500 as a 10mg lyophilized powder in a 3ml vial, tested and shipped from the United States.
Published preclinical research on Thymosin Beta 4 spans wound repair models, cardiac tissue studies, inflammatory regulation, and cell migration assays. The compound has been the subject of investigations published in Nature, The FASEB Journal, and multiple other peer reviewed journals. Every batch undergoes independent third party HPLC and mass spectrometry analysis, and a batch specific Certificate of Analysis is available on the product page below the product image in the 3rd Party Testing section.
Product Specifications
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser |
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | 4963.44 g/mol |
| CAS Number | 77591-33-4 |
| Purity | ≥99% (third party HPLC verified) |
| Form | Lyophilized (freeze dried) powder |
| Appearance | White to off-white powder |
| Vial Size | 3ml |
| Quantity | 10mg per vial |
| Testing | Independent third party HPLC and mass spectrometry |
| COA | Batch specific Certificate of Analysis included with every order |
| Origin | USA (lyophilization, testing, and shipping) |
| Storage | -20°C long term / 2-8°C short term / protect from light |
Published Preclinical Research
Thymosin Beta 4 is one of the most widely studied actin sequestering peptides in the biomedical literature. Key areas of investigation in preclinical animal and in vitro models include:
- Wound repair models — full thickness dermal wound studies in rodent models demonstrated accelerated re-epithelialization and increased collagen deposition (Malinda et al., J Investigative Dermatology, 1999)
- Cardiac tissue models — myocardial infarction models in mice showed enhanced cardiomyocyte migration and survival through integrin linked kinase and Akt signaling activation (Bock-Marquette et al., Nature, 2004)
- Angiogenesis and cell migration — studies in both normal and aged rodent models documented increased blood vessel formation and directional cell migration in controlled experimental settings (Philp et al., Annals of the New York Academy of Sciences, 2004)
- Inflammatory regulation — preclinical evidence describes modulation of NF-κB signaling, reduction of pro-inflammatory cytokines, and decreased inflammatory cell infiltration in experimental tissue models (Goldstein et al., Expert Opinion on Biological Therapy, 2012)
All data referenced on this page is derived from published preclinical animal and in vitro studies. No human clinical trials have established approved uses for TB 500.
Research Applications
- In vitro cell migration and wound closure assays (e.g., scratch assay, Boyden chamber formats) using standardized peptide exposure conditions
- Actin polymerization dynamics and G-actin/F-actin equilibrium studies in cell free and cell based systems
- Angiogenesis pathway screening using endothelial tube formation, sprouting, or proliferation assays
- Extracellular matrix (ECM) remodeling and collagen expression analysis in fibroblast culture systems
- Peptide stability and degradation analysis under buffered aqueous conditions (forced degradation and stress testing panels)
- Inflammatory signaling pathway profiling using cytokine panel readouts in controlled in vitro models
- Cardiac cell survival and integrin linked kinase activation studies in cardiomyocyte culture systems
Why Researchers Choose BioEdge for TB 500
Batch specific COA from an independent lab. Not a generic PDF recycled across products. Every vial of TB 500 is backed by independent third-party laboratory testing, with a Certificate of Analysis available for review on our product page.. HPLC confirms purity. Mass spectrometry confirms molecular identity. The COA corresponds to the specific batch you receive.
USA lyophilization. Many vendors import pre filled vials from overseas and relabel them. BioEdge sources API and performs lyophilization within the United States, maintaining direct quality control over the final product.
No filler compounds. BioEdge TB 500 is pure lyophilized peptide. No mannitol, no bulking agents, no unnecessary excipients.
Same day shipping. Domestic orders placed before cutoff ship the same day. Free shipping on orders over $150.
TB 500 Compared to BPC 157
TB 500 and BPC 157 (Body Protection Compound 157) have both been studied in preclinical tissue models, but the published literature describes different mechanisms of action. TB 500 research has primarily examined cell migration, actin regulation, blood vessel formation, and cardiac tissue models. BPC 157 research has primarily examined GI tissue integrity, connective tissue models, and nitric oxide pathway modulation.
Published preclinical protocols frequently reference both compounds because their studied mechanisms appear to be complementary rather than overlapping. BioEdge offers both compounds individually and in blended formulations:
Published References
- Malinda KM, et al. “Thymosin beta4 accelerates wound healing.” J Investigative Dermatology. 1999;113(3):364-368. PubMed
- Bock-Marquette I, et al. “Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.” Nature. 2004;432(7016):466-472. PubMed
- Philp D, et al. “Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development.” Annals of the New York Academy of Sciences. 2004;1012:44-52. PubMed
- Goldstein AL, et al. “Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications.” Expert Opinion on Biological Therapy. 2012;12(1):37-51. PubMed
- Kleinman HK, Sosne G. “Thymosin beta4 Promotes Dermal Healing.” Vitamins and Hormones. 2016;102:251-275. PubMed
Frequently Asked Questions
What is TB 500?
TB 500 is a synthetic 43 amino acid peptide corresponding to the full length sequence of Thymosin Beta 4, an endogenous actin sequestering protein found in nearly all mammalian cell types. It has been the subject of published preclinical studies in wound repair, cardiac tissue, inflammatory regulation, and cell migration models.
Where can I buy TB 500 with verified purity?
BioEdge Research Labs independently tests every batch of TB 500 via HPLC and mass spectrometry. A batch specific Certificate of Analysis ships with every order. Lyophilization is performed in the United States.
How should TB 500 be stored?
Lyophilized TB 500 should be stored at -20°C for long term or 2-8°C for short term. Protect from light and moisture.
What is the difference between TB 500 and Thymosin Beta 4?
TB 500 is a synthetic version of the naturally occurring Thymosin Beta 4 protein. In the research peptide supply chain, TB 500 refers to the full 43 amino acid synthetic sequence used in laboratory settings. The terms are used interchangeably in most published research contexts.
What is the difference between TB 500 and BPC 157?
Both have been studied in preclinical tissue models but through different mechanisms. TB 500 research focuses on actin regulation, cell migration, and cardiac models. BPC 157 research focuses on GI models and NO pathway modulation. Published protocols frequently reference both compounds together.
Is TB 500 approved for human use?
No. TB 500 is a research compound. It has not been evaluated or approved by the FDA for any human use. All products sold by BioEdge Research Labs are strictly for laboratory and research purposes.
Do you ship TB 500 within the USA?
Yes. BioEdge Research Labs is a USA based supplier with same day domestic shipping. Free shipping on orders over $150.
Can I get bulk pricing on TB 500?
Yes. Contact BioEdge Research Labs directly for institutional and bulk research pricing.
Quality Documentation
Certificate of Analysis, HPLC chromatogram, and endotoxin testing results available for each lot. View sample documentation in the 3rd Party Lab Testing tab above.
For Laboratory Research Use Only
This product is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not for diagnostic, therapeutic, or clinical applications. TB 500 has not been evaluated or approved by the FDA for any human use. All referenced studies are preclinical (animal and in vitro) and do not establish safety or efficacy in humans. BioEdge Research Labs is a chemical supplier, not a compounding pharmacy or clinical facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act.
