TB-500 (10mg)

Description

What is TB-500?

TB-500 is a synthetic peptide modeled after the naturally occurring Thymosin Beta-4 protein found in various tissues. It is currently the subject of ongoing laboratory-based scientific research. Investigations in preclinical settings—including in vitro systems and animal models—have examined its biological activity in relation to tissue repair, inflammation modulation, neuroprotection, and gastrointestinal recovery.

Researchers have explored TB-500′s influence on cell migration, angiogenesis, and cytoprotection under oxidative stress. These studies aim to expand scientific understanding of the cellular and molecular dynamics associated with tendon healing, wound closure, nerve regeneration, and epithelial recovery in controlled laboratory settings. TB-500 remains an investigational compound, and further research is needed to define its complete biological profile.

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TB-500 Product Specifications

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Why Choose BioEdge Research Labs TB-500?

• Research Grade Purity: Verified purity >99% by third-party HPLC analysis.

• Secure Packaging: Engineered to maintain peptide stability and prevent degradation during shipment.

• Fast Shipping: Most orders ship within 24 hours after payment confirmation from our U.S.-based facility

• Researcher Support: Expert customer service tailored to licensed research professionals.

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Summary of Preclinical Research Findings

Tendon Models

• Cell Migration Enhancement: TB-500 has been shown to support tendon fibroblast migration in vitro, which is crucial to cellular repopulation and matrix remodeling.

• Signaling Pathways: Research indicates activation of focal adhesion kinase (FAK) and related pathways implicated in cell adhesion and structural reorganization.

• Oxidative Stress Tolerance: Preclinical evidence suggests increased tendon cell viability under oxidative conditions.

• Collagen Support: TB-500 may contribute to collagen expression, which is fundamental for extracellular matrix integrity and tensile strength.

Inflammation Modulation

• Reduction of Inflammatory Cytokines: Experimental studies report lowered levels of pro-inflammatory signals in affected tissue.

• Immune Cell Regulation: Observed reductions in inflammatory cell infiltration in vivo.

• Comparative Anti-inflammatory Activity: Demonstrated beneficial modulation of inflammatory responses without hindering regenerative activity, in contrast to corticosteroids.

Neuroprotection

• Neuronal Survival: In vitro research suggests protective effects on neuronal viability post-injury.

• Axonal Regeneration: Animal studies report enhanced nerve regeneration processes.

• Cognitive Function Recovery: Preliminary models have explored its potential in supporting post-trauma neurological function.

Gastrointestinal Recovery

• Mucosal Healing: Preclinical models suggest that TB-500 may assist in epithelial regeneration and restoration of gut lining integrity.

• Anti-inflammatory GI Effects: Reduction in inflammatory damage in intestinal models has been reported.

• Support for Cellular Turnover: Evidence indicates enhanced intestinal epithelial cell proliferation under controlled conditions.

Note: All research described above is derived from non-human laboratory experimentation. No claims are made regarding use, safety, or efficacy in humans or animals.

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Suggested Research Applications

• Tendon and ligament recovery studies

• Gastrointestinal epithelial modeling

• Nerve repair and neuroregeneration research

• Inflammation and oxidative stress investigations

• Muscle injury and recovery protocols

• Cell migration and angiogenesis studies

These applications are provided for informational purposes only to support experimental design by qualified researchers. No therapeutic or diagnostic implications are expressed or implied.

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Handling & Storage Guidelines

• Store lyophilized peptide at room temperature upon arrival.

• After reconstitution, refrigerate immediately.

• Use only sterile solvents appropriate for your laboratory protocol.

• Protect from direct light and moisture for maximum compound stability.

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For Research Use Only

BioEdge Research Labs’ TB-500 is supplied exclusively for research and laboratory use.

• Not for human or animal consumption.

• Not for diagnostic, therapeutic, or clinical application.

• Not for resale or off-label use.

By purchasing this product, you affirm your understanding of and agreement to these terms. BioEdge Research Labs accepts no liability for misuse. Content is intended for informational purposes only. It is the researcher’s responsibility to comply with all applicable laws and regulations. Must be 18 years or older to purchase.

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Summary of References

TB-500 Tendon Healing and Fibroblast Migration

• Lee, J.Y., et al. (2013). Thymosin Beta 4 enhances the healing of medial collateral ligament in rat. Am J Sports Med, 41(7), 1440–1447. https://pubmed.ncbi.nlm.nih.gov/23523891

• Philp, D., et al. (2010). Thymosin Beta 4 enhances repair by organizing connective tissue in skin wound healing. J Invest Dermatol, 130(1), 287–294. https://pubmed.ncbi.nlm.nih.gov/20536458

TB-500 Inflammation Modulation

• Li, J., et al. (2018). Thymosin Beta 4 prevents oxidative stress, inflammation, and fibrosis in ethanol- and LPS-induced liver injury. Oxid Med Cell Longev, 2018, Article ID 9637560. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079392

• Sosne, G., et al. (2018). Thymosin Beta 4 limits inflammation through autophagy. Curr Pharm Des, 24(30), 3540–3547. https://pubmed.ncbi.nlm.nih.gov/30063848

TB-500 Neuroprotective Properties

• Xiong, Y., et al. (2012). Neuroprotective and neurorestorative effects of Thymosin Beta 4 following traumatic brain injury. Ann N Y Acad Sci, 1270(1), 51–58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547647

• Wang, Y., et al. (2019). Thymosin Beta 4 and electroacupuncture tolerance development. Evid Based Complement Alternat Med, 2019, Article ID 6214158. https://pubmed.ncbi.nlm.nih.gov/30971892

TB-500 in Gut Health and GI Repair

• Tomaselli, G., et al. (2011). Immunoreactivity of Thymosin Beta 4 in human gastrointestinal tract. Eur J Histochem, 55(3), e29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167329

• Goldstein, A.L., et al. (2012). Thymosin Beta 4: A multifunctional regenerative peptide. Expert Opin Biol Ther, 12(1), 37–51. https://pubmed.ncbi.nlm.nih.gov/22074294

 

BioEdge Research Labs
Precision. Purity. Performance.

At BioEdge, we are committed to providing research professionals with the highest quality peptides on the market. Every compound we supply is manufactured in a cGMP-certified facility, undergoes rigorous third-party testing, and is intended strictly for in vitro or laboratory research use only.