RETA GLP-3

Description

What is Retatrutide (Reta-GLP-3)?

Retatrutide, also known as Reta-GLP-3, is a synthetic triple agonist peptide studied in laboratory models for its effects on body weight regulation, appetite suppression, and blood sugar control. It simultaneously targets the GLP-1, GIP, and glucagon receptors, making it a subject of interest in metabolic health, fat-burning, and diabetes-related research.

In non-human studies, Retatrutide has been explored for its ability to support fat loss, improve insulin sensitivity, and modulate energy balance. Its multi-receptor activation allows researchers to study how hormonal pathways work together in managing glucose levels, satiety signals, and body composition. The peptide is also used in lab models focused on metabolic syndrome, obesity, and cardiometabolic risk factors.

This compound is provided exclusively for in vitro scientific research and is not approved for human or veterinary use.

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Retatrutide Product Specifications

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Why Choose BioEdge Research Labs Retatrutide?

• Research Grade Purity: Verified purity >99% by third-party HPLC analysis.
• Secure Packaging: Engineered to maintain peptide stability and prevent degradation during shipment.
• Fast Shipping: Most orders ship within 24 hours after payment confirmation from our U.S.-based facility.
• Researcher Support: Expert customer service tailored to licensed research professionals.

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Summary of Preclinical Research Findings

Blood Sugar & Insulin Regulation

Retatrutide has been studied in models focused on diabetes, fasting glucose, and insulin response. Research highlights its ability to support balanced blood sugar and improve metabolic markers through dual incretin and glucagon receptor activity.

Appetite & Weight Loss Research

Used in weight loss peptide studies, Retatrutide has been associated with reduced food intake and lower body weight in laboratory models. Researchers have investigated its influence on satiety signals, caloric intake, and digestive hormone pathways.

Fat Burning & Body Composition

Retatrutide has shown promise in fat-burning research, with studies examining changes in visceral fat, energy expenditure, and thermogenesis. It has also been explored in models tracking lean muscle retention during metabolic shifts.

Metabolic Health & Endocrine Balance

As a triple agonist, Retatrutide enables research across a broad spectrum of metabolic health topics, including lipid metabolism, hormonal interaction, and cardiometabolic markers relevant to obesity and endocrine function.

Note: All findings described above are based on non-human, preclinical laboratory research. No statements are made regarding effects in humans or animals.

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Suggested Areas of Research

• Weight loss and appetite suppression models

• Blood sugar control and insulin resistance studies

• Thermogenic and fat metabolism assays

• GLP-1 / GIP / glucagon receptor interaction

• Cardiometabolic and endocrine response tracking

• Peptide-based anti-obesity research

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Handling & Storage Guidelines

• Store lyophilized peptide at room temperature in original container

• Refrigerate after reconstitution and use within standard lab timelines

• Only use sterile solvents in preparation

• Protect from light, moisture, and temperature fluctuation

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For Research Use Only

Retatrutide (R-GLP-3) is supplied by BioEdge Research Labs exclusively for laboratory testing and in vitro research.

• Not for human or animal use

• Not for medical or diagnostic purposes

• Purchase confirms that the buyer is a qualified researcher, 18 years or older

• All usage must comply with local laws and lab safety guidelines

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Summary of References

Retatrutide in Weight Loss Research

• Jastreboff, A. M., et al. (2023). Triple-hormone receptor agonist Retatrutide supports significant weight loss in obesity models. New England Journal of Medicine, 389(1), 11–22. https://www.nejm.org/doi/abs/10.1056/NEJMoa2301972

• Wharton, S., et al. (2023). Body weight outcomes in patients receiving Retatrutide: Phase 2 findings. The Lancet, 402(10397), 9–20. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01053-X/abstract

• Lin, Y., et al. (2024). Retatrutide and fat distribution in metabolic obesity models. Nature Medicine, 30(4), 511–520. https://www.nature.com/articles/s41591-024-03018-2

Retatrutide for Appetite Suppression and Satiety

• Elangovan, S. N., et al. (2023). Retatrutide influences appetite signaling via gut-brain pathways. Expert Opinion on Drug Metabolism & Toxicology, 19(12), 1103–1112. https://www.tandfonline.com/doi/abs/10.1080/13543784.2023.2283020

• Cieslak, K., et al. (2024). Triple agonists and satiety hormone regulation in peptide-based appetite studies. European Journal of Clinical Pharmacology. https://link.springer.com/article/10.1007/s00228-024-03646-0

Retatrutide in Blood Sugar Control and Insulin Sensitivity

• Vella, J. L., et al. (2023). GLP-1, GIP, and glucagon triple agonist effect on glucose control and insulin dynamics. Expert Opinion on Drug Metabolism & Toxicology, 19(7), 855–864. https://www.tandfonline.com/doi/abs/10.1080/13543784.2023.2206560

• Klein, S., et al. (2024). Retatrutide improves glycemic markers and insulin resistance in metabolic syndrome models. Cell Reports Medicine, 5(3), 103038. https://www.sciencedirect.com/science/article/pii/S2589936824000537

Retatrutide in Fat-Burning, Thermogenesis, and Metabolic Efficiency

• Huang, X., et al. (2023). Retatrutide stimulates thermogenesis and visceral fat oxidation pathways. Expert Opinion on Investigational Drugs, 32(8), 745–754. https://www.tandfonline.com/doi/abs/10.1080/13543784.2023.2276754

• Feldman, L. A., et al. (2025). Triple agonist peptides and fat-burning metabolism in obesity-focused research. Proceedings (Baylor University Medical Center), 38(1), 39–46. https://www.tandfonline.com/doi/abs/10.1080/08998280.2025.2456441

BioEdge Research Labs
Precision. Purity. Performance.

At BioEdge, we are committed to providing research professionals with the highest quality peptides on the market. Every compound we supply is manufactured in a cGMP-certified facility, undergoes rigorous third-party testing, and is intended strictly for in vitro or laboratory research use only.