PE 22-28 (8mg)

Description

What is PE-22-28?

PE-22-28 is a synthetic research peptide derived from the spadin sequence, commonly studied for its potential influence on mood, depression, cognitive function, and neuroprotection. In preclinical models, PE-22-28 has been shown to interact with the TREK-1 potassium channel, a target associated with serotonin signaling and emotional regulation.

Research has also explored PE-22-28’s effects in areas such as post-stroke recovery, muscle coordination, and stress-related behavior. Its unique properties have made it a focus in studies of brain health, synaptic plasticity, and motor function.

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PE-22-28 Product Specifications

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Why Choose BioEdge Research Labs PE-22-28?

Research Grade Purity: Verified purity >99% by third-party HPLC analysis.
Secure Packaging: Designed to maintain peptide stability and prevent degradation during shipment and storage.
Rapid Fulfillment: Most orders ship within 24 hours after payment confirmation.
Researcher Support: Expert customer service tailored to licensed research professionals.

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Summary of Preclinical Research Findings

Mood Regulation and Depression

PE-22-28 has been studied for its potential to modulate serotonin activity through TREK-1 inhibition, which may influence mood balance and depression-related behavior in lab settings. In preclinical studies, it has shown rapid-acting antidepressant-like effects.

Cognitive Function and Post Stroke Brain Recovery

This peptide has demonstrated promise in supporting learning and memory in models of brain injury and stroke recovery. Findings suggest it may promote synaptic plasticity, protect neurons, and assist in functional restoration after neurological damage.

Muscle Function and Motor Coordination

Studies have examined PE-22-28 for its role in muscle control and motor performance, particularly in the context of neuromuscular signaling and post-stroke rehabilitation models. It may help researchers explore how neural pathways influence movement and strength.

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Suggested Areas of Research

• Depression and serotonin signaling

• Cognitive function and memory support

• Post-stroke recovery and brain repair

• Muscle function and motor coordination

• Neuroprotection and plasticity

• TREK-1 channel modulation

• Stress response and mood behavior models

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Handling & Storage Guidelines

• Store lyophilized peptide in a cool, dry place

• Refrigerate after reconstitution

• Use sterile laboratory solvents

• Protect from heat, light, and moisture

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For Research Use Only

PE-22-28 is supplied by BioEdge Research Labs exclusively for laboratory testing and in vitro research.

• Not for human or animal use

• Not for medical or diagnostic purposes

• Purchase confirms that the buyer is a qualified researcher, 18 years or older

• All usage must comply with local laws and lab safety guidelines

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Summary of References

PE-22-28 in Mood and Depression Research

• Djillani, A. et al. (2017). Shortened spadin analogs display better TREK-1 inhibition and antidepressant activity. Frontiers in Pharmacology, 8, 336. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601071/

• Mazella, J. et al. (2010). Spadin as a new antidepressant targeting TREK-1. Molecular Psychiatry, 15(9), 823–835. https://pubmed.ncbi.nlm.nih.gov/20405001/

PE-22-28 in Brain Function and Stroke Models

• Djillani, A. et al. (2019). Neurotrophic and neuroprotective effects of TREK-1 inhibition in stroke models. Journal of the Neurological Sciences, 405, 116428. https://www.jns-journal.com/article/S0022-510X(19)31211-0/fulltext

• El Yacoubi, M. et al. (2014). Functional recovery and brain plasticity after spadin analog administration. Brain Structure and Function, 220(5), 2935–2946. https://doi.org/10.1007/s00429-014-0890-x

PE-22-28 in Muscle and Motor Control Studies

• Li, M. et al. (2014). TREK-1-related modulation of motor circuits in CNS. Biological Psychiatry, 50(1), 35–41. https://doi.org/10.1016/S0893-133X(01)00358-X

• Maingret, F. et al. (2014). Role of potassium channels in neural-motor coordination. PubMed, 24801307. https://pubmed.ncbi.nlm.nih.gov/24801307/

 

BioEdge Research Labs
Precision. Purity. Performance.

At BioEdge, we are committed to providing research professionals with the highest quality peptides on the market. Every compound we supply is manufactured in a cGMP-certified facility, undergoes rigorous third-party testing, and is intended strictly for in vitro or laboratory research use only.