KLOW: GHK-Cu, KPV, BPC-157 and TB-500

Description

What is KLOW?

KLOW is a comprehensive four-peptide research formulation that combines GHK-Cu (50 mg), KPV (10 mg), BPC-157 (10 mg), and TB-500 (10 mg) in one synergistic vial. Each component has been independently investigated for its potential roles in tissue regeneration, inflammation control, wound healing, collagen synthesis, and systemic recovery. Together, these peptides provide a multifaceted approach for exploring biological repair and resilience mechanisms in laboratory settings.

GHK-Cu has been studied for its ability to stimulate collagen production, angiogenesis, and skin repair. KPV (Lys-Pro-Val) has demonstrated potent anti-inflammatory and antimicrobial effects, often studied in models of gut and epithelial barrier protection. BPC-157 is a gastric-derived peptide explored for tendon, ligament, and gastrointestinal repair, while TB-500, a synthetic fragment of Thymosin Beta-4, is known for its role in actin regulation and soft-tissue healing.

Collectively, KLOW allows researchers to examine synergistic pathways across cellular regeneration, immune modulation, and tissue homeostasis.

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KLOW Product Specifications

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Why Choose BioEdge Research Labs KLOW?

• Research Grade Purity: Verified >99% by third-party HPLC analysis

• Secure Packaging: Designed to maintain peptide stability and prevent degradation during shipment and storage

• Rapid Fulfillment: Most orders ship within 24 hours of payment confirmation from our U.S. facility

• Researcher Support: Dedicated customer service tailored to licensed research professionals

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Summary of Preclinical Research Findings

Collagen Synthesis & Skin Regeneration

GHK-Cu has been widely explored for its role in skin rejuvenation, wound repair, and hair follicle stimulation. Research indicates it may upregulate collagen, elastin, and glycosaminoglycan synthesis while enhancing angiogenesis and antioxidant defenses.

Inflammation & Immune Regulation

KPV demonstrates strong anti-inflammatory properties by modulating cytokine activity and down-regulating pro-inflammatory pathways in epithelial and mucosal tissues. When combined with BPC-157 and TB-500, studies suggest an amplified effect on systemic inflammatory balance and cellular protection.

Muscle & Connective Tissue Repair

BPC-157 and TB-500 have been extensively studied in tendon, ligament, and muscle injury models. Together they support fibroblast migration, angiogenesis, and tissue remodeling—key processes in soft-tissue regeneration and performance recovery research.

Gut & Epithelial Barrier Integrity

Both KPV and BPC-157 have demonstrated potential in restoring intestinal barrier function and promoting mucosal healing. Their combination offers a compelling model for studying epithelial protection and gut-immune signaling.

Systemic Resilience & Neuroprotection

Research on TB-500 and GHK-Cu has indicated neuroprotective and cytoprotective potential, suggesting possible utility in models of oxidative stress, aging, and neural repair.

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Suggested Areas of Research

• Collagen and extracellular-matrix formation

• Wound healing and skin regeneration

• Tendon, ligament, and joint recovery

• Gut lining and epithelial barrier repair

• Anti-inflammatory and immune-response studies

• Muscle recovery and oxidative-stress reduction

• Angiogenesis and tissue oxygenation

• Cellular repair and aging-model research

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Handling & Storage Guidelines

• Store lyophilized peptide in a cool, dry place

• Refrigerate after reconstitution

• Use only sterile, laboratory-grade solvents

• Protect from heat, moisture, and light

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For Research Use Only

KLOW is supplied by BioEdge Research Labs exclusively for laboratory testing and in vitro research.

• Not for human or animal use

• Not for medical or diagnostic purposes

• Purchase confirms that the buyer is a qualified researcher, 18 years or older

• All usage must comply with local laws and lab safety guidelines

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Summary of References

BPC-157 Wound Healing and Granulation Tissue Formation

• Sikiric, P., Seiwerth, S., & Staresinic, M. (1993). The effect of BPC 157 on granulation tissue formation, angiogenesis, and collagen production in rat skin wounds. Journal of Physiology and Pharmacology, 44(4), 413–421. https://pubmed.ncbi.nlm.nih.gov/9403790/
• Zoric, Z., et al. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Journal of Surgical Research, 194(2), 469–477. https://doi.org/10.1016/j.jss.2014.10.015

KPV in Skin and Wound Healing

• Lee, Y.J., et al. (2015). KPV reduces cytokine activity and supports re-epithelialization in wounded skin. Journal of Investigative Dermatology, 135(10), 2503–2512. https://www.sciencedirect.com/science/article/pii/S0022202X15307697

• Ward, D.B., et al. (2022). Healing effects of KPV-loaded hydrogels on burn wounds. Regenerative Therapy, 21, 124–133. https://www.sciencedirect.com/science/article/pii/S174270612200126X

TB-500 Inflammation Modulation

• Li, J., et al. (2018). Thymosin Beta 4 prevents oxidative stress, inflammation, and fibrosis in ethanol- and LPS-induced liver injury. Oxid Med Cell Longev, 2018, Article ID 9637560. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079392

GHK-Cu in Anti-Inflammatory and Antioxidant Studies

• Abbas, M., et al. (2015). GHK-Cu as a modulator of oxidative stress in inflammation-driven skin models. Bioorganic & Medicinal Chemistry Letters, 25(24), 5590–5593. https://www.sciencedirect.com/science/article/pii/S0960894X14013262

• Mazurowska, L., & Mojski, M. (2017). GHK-Cu peptide shows antioxidant activity and protective effect against UV-induced oxidative damage. Acta Poloniae Pharmaceutica, 74(1), 255–260. https://www.ncbi.nlm.nih.gov/pubmed/28212278

 

BioEdge Research Labs
Precision. Purity. Performance.

At BioEdge, we are committed to providing research professionals with the highest quality peptides on the market. Every compound we supply is manufactured in a cGMP-certified facility, undergoes rigorous third-party testing, and is intended strictly for in vitro or laboratory research use only.