AOD-9604 (5MG)

Description

What is AOD-9604?

AOD-9604 is a synthetic peptide fragment derived from the C-terminal end of human growth hormone (hGH), corresponding to amino acids 177–191. It has been extensively studied for its lipolytic (fat metabolism) properties without the broader growth-promoting effects of full-length hGH.

In preclinical research, AOD-9604 has been investigated for its ability to stimulate fat breakdown (lipolysis) and inhibit lipogenesis, particularly in models of obesity, metabolic syndrome, and energy balance. Studies suggest it may act through beta-adrenergic independent mechanisms, providing a unique pathway for studying adipose tissue regulation.

The compound is supplied with 3mL of Acetic Acid (0.6%) for reconstitution, ensuring optimal peptide stability and solubility for laboratory preparation.

AOD-9604 Product Specifications

Product: AOD-9604 5mg lyophilized peptide vial
Included: 3mL Acetic Acid (0.6%) for reconstitution
Purity: >99% (HPLC Verified)
Form: White Lyophilized Powder
Storage Conditions: Store at room temperature before reconstitution; refrigerate after reconstitution
Stability: 24 months when stored properly

Summary of Preclinical Research Findings

Fat Metabolism and Lipolysis

AOD-9604 has been studied for its ability to enhance lipolysis and reduce lipogenesis in adipose tissue. Research demonstrates that it may activate fat oxidation and mobilization processes without stimulating insulin resistance or altering glucose metabolism.

Body Composition and Energy Balance

In rodent and in vitro models, AOD-9604 has been shown to influence body composition by selectively reducing fat mass while preserving lean tissue. Its unique mechanism provides a valuable tool for exploring metabolic rate regulation and energy expenditure independent of traditional GH pathways.

Metabolic Health and Obesity Models

Preclinical studies suggest AOD-9604 may aid in maintaining metabolic equilibrium in high-fat diet and obesity models. It has been used to investigate potential links between GH fragments, adipocyte metabolism, and thermogenic activation in brown and white fat tissue.

Cartilage and Tissue Regeneration

Emerging studies have explored AOD-9604’s potential effects on cartilage protection and repair through localized GH fragment signaling, making it of growing interest in regenerative and orthopedic research.

Suggested Research Applications

• Lipolytic and fat metabolism studies

• Body composition and energy regulation models

• Thermogenesis and adipocyte activation research

• Non-GH-mediated metabolic pathway exploration

• Regenerative and cartilage support assays

• Obesity and metabolic syndrome studies

Why Choose BioEdge Research Labs AOD-9604 Peptide?

• High Purity: >99% verified via third-party HPLC testing

• Secure Packaging: Tamper-resistant vials protect peptide structure

• Fast Shipping: Most orders ship within 24 hours of payment confirmation from our U.S.-based facility

• Researcher-Focused Support: Dedicated service for lab professionals

• Regulatory Compliance: Not for human or veterinary use; research use only

For Research Use Only

AOD-9604 is supplied by BioEdge Research Labs exclusively for laboratory and in vitro research.

• Not for human or animal use

• Not for medical or diagnostic purposes

• Purchase confirms that the buyer is a qualified researcher, 18 years or older

• All usage must comply with local laws and lab safety guidelines

Summary of References

AOD-9604 in Fat Metabolism and Lipolysis

Heffernan, M. A., Ng, F. M., & Bornstein, J. (2001). Effects of human growth hormone and its C-terminal fragment (AOD9604) on lipid metabolism following chronic treatment in obese and β3-adrenergic receptor knockout mice. Endocrinology, 142(12), 5182–5189. https://academic.oup.com/endo/article-pdf/142/12/5182/10363052/endo5182.pdf

Ng, F. M., & Bornstein, J. (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Hormone Research in Paediatrics, 53(6), 274–278. https://karger.com/hrp/article/53/6/274/371690

Halford, J. C. G., et al. (2006). Obesity drugs in clinical development: Pharmacological and biochemical insights. Obesity Reviews, 7(1), 25–36. https://www.researchgate.net/profile/Jason-Halford/publication/7154334_Obesity_drugs_in_clinical_development/links/09e4150694f5675e10000000/Obesity-drugs-in-clinical-development.pdf

AOD-9604 in Clinical Safety and Human Research

Stier, H., Vos, E., & Kenley, D. (2013). Safety and tolerability of the hexadecapeptide AOD9604 in humans. Journal of Endocrinology and Metabolism, 3(1–2), 7–15. https://jofem.org/index.php/jofem/article/download/157/195

Annals of Clinical & Laboratory Science. (2015). Laboratory detection and analysis of growth hormone fragments and related peptides. Annals of Clinical & Laboratory Science, 45(4), 426–433. https://www.annclinlabsci.org/content/45/4/426.full.pdf

AOD-9604 in Analytical and Detection Research

McLeod, J., et al. (2012). Detection of AOD9604 and related peptides in biological matrices: Method development and validation. Drug Testing and Analysis, 4(8), 600–606. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.1715

University of Toronto Scholaris Repository. (2022). Peptide-mediated lipolysis and metabolic regulation: Characterization of GH fragments including AOD9604. https://utoronto.scholaris.ca/items/9cedc766-f5b6-4459-ba6b-3e67fae4e88a

BioEdge Research Labs
Precision. Purity. Performance.

At BioEdge, we are committed to providing research professionals with the highest quality peptides on the market. Every compound we supply is manufactured in a cGMP-certified facility, undergoes rigorous third-party testing, and is intended strictly for in vitro or laboratory research use only.